Connor Scott

Connor Scott

Research Assistant / D.Phil Student

Nuffield Department of Clinical Neurosciences

Biography

Connor Scott is a neuroscientist with over 7 years of human tissue experience, specialising in bringing traditional histology into the modern era by developing workflows to bridge neuropathology with multiple ‘omic’ technologies using surgical and post-mortem CNS material.

Scroll down to see a brief overview of his academic profile or click on the headings above to get a more in-depth view.

Interests

  • Neurodegeneration
  • Laser Capture Microdissection
  • Digital Pathology
  • Machine Learning
  • Proteomics / Transcriptomics

Education

  • D.Phil (Oxon) in Clinical Neurosciences, (current)

    University of Oxford

  • BSc (Hons) in Biomedical Sciences, 2012

    University of Greenwich

Skills

qPCR

Neuropathology - Human Tissue

Proteomics / Transcriptomics

RNAscope / Immunostaining

Laser Microdissection

Molecular Biology

Data Analysis

Bioinformatics

Image Analysis

Employment Experience

 
 
 
 
 

Research Assistant

Nuffield Department of Clinical Neurosciences - University of Oxford

Jun 2015 – Present Oxford

Responsibilities include:

  • Senior Research Scientist.
    Current projects: (1) selective vulnerability in amyotrophic lateral sclerosis, (2) early detection of Alzheimer’s Disease, (3) novel biomarker discovery in Alzheimer’s disease, (4) microproteomics of rare neuronal cell types/tumour samples, (5) genetic classification of gliomas, (6) High-resolution MRI scanning.

  • Establishing, managing, and maintaining several core research facilities within NDCN. This includes providing training and troubleshooting.
    Facilities: Whole Slide Digital Imaging, Automated IHC/ISH and Laser Microdissection.

  • Day to day advisory role for post-graduates (MSc, MRes, D.Phil) and post-doctoral scientists.

  • Specialized training to students (undergraduates/postgraduates) and professionals (laboratory technicians, research assistants, post-doctoral researchers).

  • Supervisory role on several FHS research projects; both for medical students and undergraduates. Experience managing students, determining project direction, placing deadlines, managing student concerns, and helping students reach their targets.

    Click Employment Experience for a detailed summary.

Grants/Awards

Research Grant - £5000

For research to support the advancement of Neuropathology. In this case - Single-cell RNA-Sequencing of post-mortem motor neurons.

Public Engagement Award - £1000

Grant awarded to allow us to partake in an educational programme to perform hands-on science experiments with students, explain our research, and provide scientific career advice.

NIHR Oxford Biomedical Research Centre Training Bursary - £5000

This scheme funds short courses or modules which will provide training and expertise in research skills or research management.

Partnership Progression Scholarship

This Scholarship is awarded to the 10 highest achieving students that achieve a first-class honour in all academic years during their studies.

Extracurricular

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Sir Charles Sherrington and Sir Wilfrid Le Gros Clark Collections

Digital microscopist for these historic collections. Click for more information.

University of Oxford, Graduate President.

President of graduate students at one of University of Oxford’s colleges - Somerville College. Click for more information.

University of Oxford, Social Secretary.

Social Secretary - Somerville College. Click for more information.

Neuropath EQA scheme (NEQAS)

The Neuropathology EQA scheme (NEQAS) forms part of a national system of quality assurance to healthcare organisations that is being maintained and improved. Click for more information.

Healthcare Assistant - Acute Cardiac Ward.

For 4 months I acted as a volunteer in this Unit. My task ranged from taking vitals such as blood pressure/o2 saturation to feeding and clothing patients. I would travel with nervous or disabled patients to their external GP appointments and would relay information from doctors between departments.

Healthcare Assistant - Acute Elderly Ward.

For 6 months I volunteered in this NHS ward. My primarily goal was to ensure all patients were comfortable and happy with their stay. I would frequently join ward rounds and sit down with patients and discuss how they were feeling/discussed what we could do to make their stay more comfortable on top of just being a friendly face for them to talk to.

Volunteer - Ellenor Hospice.

For 6 months I volunteered in an Ellenor Hospice. The primary objective was to make patients as comfortable as possible while they received palliative care.

Recent Publications

Quickly discover relevant content by filtering publications.

Development of a Sensitive, Scalable Method for Spatial, Cell-Type-Resolved Proteomics of the Human Brain

Developing a technique that allows for differential quantitative proteomic analysis to be performed on minute amount of post-mortem laser microdissected material.

Abstracts & Posters

Quickly discover relevant content by filtering abstracts/posters.

Spatially resolved MALDI mass spectrometric imaging of human brain tissue for metabolites, lipids, and peptides - proof of principle

In this proof of principle experiment, we demonstrate that MALDI-MSI combined with classical LCM LC-MS/MS has the potential to spatially resolve metabolic signatures in human brain at cellular resolution. Abstract & Talk given - The Oxford Metabolic Health Symposium 2020, 30th June – 3rd July 2020.

Molecular imaging of human brain tumour tissue by mass spectrometry

LC-MS based mass spectrometry imaging of proteins has the potential to provide novel insights into the proteome of tissues. Abstract - Presented at the Oxford Metabolic Health Symposium 2020, 30th June – 3rd July 2020.

High throughput, spatially-resolved proteomic analysis of a human brain tumour

Here we apply a sensitive, spatially resolved workflow for the proteomic analysis of a tumour to identify proteins that display spatial expression patterns within the tissue in an unsupervised manner. Abstract and Poster - ASMS Conference on Mass Spectrometry and Allied Topics, May 31st - June 4th 2020.

The BigMac dataset - linking tissue microstructure with diffusion MRI signals throughout the brain

Linking tissue microstructure with diffusion MRI signals throughout the brain Abstract and Poster - Whistler Scientific Workshop on Brain Functional Organization, Connectivity, and Behavior, March 1st - March 4th 2020.

Understanding the pathophysiological role of early tau aggregates in Alzheimer's disease by their direct visualisation in situ

Presented at 121st Meeting of the British Neuropathological Society, Developmental Neuropathology Symposium, 4th – 6th March 2020. Published Poster - Journal of Neuropathology and Applied Neurobiology.

Contact

  • Neuropathology Department, Level One, West Wing, John Radcliffe Hospital, Oxford, Oxfordshire OX3 9DU
  • Enter either West Wing or Children’s Hospital Entrance, go to Level One and ring the bell.
  • DM Me
  • Skype Me