Connor Scott

Connor Scott

Senior Histology Manager (UCL) / Hononary Academic (Oxford)

UK Dementia Research Institute

Nuffield Department of Clinical Neurosciences

Biography

Connor Scott is a neuroscientist with over 9 years working in the biomedical field. He has extensive experience with human tissue, histology, molecular biology, and cellular biology. He specialises in bringing traditional histology into the modern era by developing workflows to bridge neuropathology with multiple ‘omic’ technologies using clinical, surgical, and post-mortem CNS material.

Scroll down to see a brief overview of his academic profile or click on the headings above to get a more in-depth view.

Interests

  • Cell Biology
  • Machine Learning
  • Molecular Biology
  • Neurodegeneration
  • Oncology

Education

  • D.Phil/PhD in Clinical Neurosciences, 2021

    University of Oxford

  • BSc (Hons) in Biomedical Sciences, 2012

    University of Greenwich

Skills

qPCR

Neuropathology - Human Tissue

Proteomics / Transcriptomics

RNAscope / Immunostaining

Laser Microdissection

Molecular Biology

Data Analysis

Bioinformatics

Image Analysis

Employment Experience

 
 
 
 
 

Senior Histology Manager

UK Dementia Research Institute - UCL

Jun 2021 – Present London

Responsibilities include:

  • Set up and established a new research laboratory to allow scientists to perform molecular neuroscience/neuropathology experiments for their desired projects.

  • Establish, manage, and maintain several core research equipment within UKDRI UCL. This includes providing training, troubleshooting, and managing access.

  • Provide scientific guidance, training, and advice to scientists of all levels. This takes the form of guidance for general histology, molecular biology, or experimental design.

  • Responsible for the technical, scientific and governance management of the UK DRI at UCL Histology Facility.

  • Provide guidance to ensure UCL laboratories are compliant with the Human Tissue Act 2004 and following best practices approved by the Human Tissue Authority.

  • Manage laboratory budgets and develop cost-recovery models.

Click Employment Experience for a full detailed summary.

 
 
 
 
 

Honorary Academic

University of Oxford - Nuffield Department of Clinical Neurosciences

May 2021 – Present Oxford
Current projects:
(1) Selective vulnerability of subpopulation of neurons in amyotrophic lateral sclerosis.
(2) Researching how epigenetics underpins cell-state fate and cellular signatures,
(3) Microproteomics of rare neuronal cell types/tumour samples.

  • Day to day advisory role for post-graduates (MSc/MRes, D.Phil) and post-doctoral scientists.

Grants/Awards

Research Grant - £5000

For research to support the advancement of Neuropathology. In this case - Single-cell RNA-Sequencing of post-mortem motor neurons.

Public Engagement Award - £1000

Grant awarded to allow us to partake in an educational programme to perform hands-on science experiments with students, explain our research, and provide scientific career advice.

NIHR Oxford Biomedical Research Centre Training Bursary - £5000

This scheme funds short courses or modules which will provide training and expertise in research skills or research management.

Partnership Progression Scholarship

This Scholarship is awarded to the 10 highest achieving students that achieve a first-class honour in all academic years during their studies.

Extracurricular

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Sir Charles Sherrington and Sir Wilfrid Le Gros Clark Collections

Digital microscopist for these historic collections. Click for more information.

University of Oxford, Graduate President.

President of graduate students at one of University of Oxford’s colleges - Somerville College. Click for more information.

University of Oxford, Social Secretary.

Social Secretary - Somerville College. Click for more information.

Neuropath EQA scheme (NEQAS)

The Neuropathology EQA scheme (NEQAS) forms part of a national system of quality assurance to healthcare organisations that is being maintained and improved. Click for more information.

Editor - English Editing Service

With regard scientific papers, MogoEdit provides two editing models: standard polishing and in-depth editing. Standard paper polishing mainly focuses on correcting errors in language, including word use, expressions, grammar, and sentence structure.

Recent Publications

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Abstracts & Posters

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The microscopy connectome towards 3D PLI tractography in the BigMac dataset

Here, we reconstruct 3D fibre orientations from 2D microscopy images in the BigMac dataset. This will facilitate future determination of the ultra-high resolution microscopy connectome, with applications in basic neuroanatomy and tractography design.

Automatic extraction of reproducible semi-quantitative histological metrics for MRI-histology correlations

Here, we describe an end-to-end pipeline for the extraction of a histological metric from IHC stains to quantify a microstructural feature. We compare the pipeline’s reproducibility and robustness to histology artefacts, relative to manual MRI-histology analyses.

Spatially resolved MALDI mass spectrometric imaging of human brain tissue for metabolites, lipids, and peptides - proof of principle

In this proof of principle experiment, we demonstrate that MALDI-MSI combined with classical LCM LC-MS/MS has the potential to spatially resolve metabolic signatures in human brain at cellular resolution. Abstract & Talk given - The Oxford Metabolic Health Symposium 2020, 30th June – 3rd July 2020.

Molecular imaging of human brain tumour tissue by mass spectrometry

LC-MS based mass spectrometry imaging of proteins has the potential to provide novel insights into the proteome of tissues. Abstract - Presented at the Oxford Metabolic Health Symposium 2020, 30th June – 3rd July 2020.

High throughput, spatially-resolved proteomic analysis of a human brain tumour

Here we apply a sensitive, spatially resolved workflow for the proteomic analysis of a tumour to identify proteins that display spatial expression patterns within the tissue in an unsupervised manner. Abstract and Poster - ASMS Conference on Mass Spectrometry and Allied Topics, May 31st - June 4th 2020.

Contact

  • Neuropathology Department, Level One, West Wing, John Radcliffe Hospital, Oxford, Oxfordshire OX3 9DU
  • Enter either West Wing or Children’s Hospital Entrance, go to Level One and ring the bell.
  • DM Me
  • Skype Me